Optimization of miRNA-seq data preprocessing

Optimization of miRNA-seq data preprocessing

The past two decades of microRNA (miRNA) research has solidified the role of these small non-coding RNAs as key regulators of many biological processes and promising biomarkers for disease. The concurrent development in high-throughput profiling technology has further advanced our understanding of the impact of their dysregulation on a global scale. Currently, next-generation sequencing is the ...

miRNA-Seq normalization comparisons need improvement.

A Generic Preprocessing Optimization Methodology when Predicting Time-Series Data

A general Methodology referred to as Daphne is introduced which is used to find optimum combinations of methods to preprocess and forecast for time-series datasets. The Daphne Optimization Methodology (DOM) is based on the idea of quantifying the effect of each method on the forecasting performance, and using this information as a distance in a directed graph. Two optimization algorithms, Genet...

Enhancing Learning from Imbalanced Classes via Data Preprocessing: A Data-Driven Application in Metabolomics Data Mining

This paper presents a data mining application in metabolomics. It aims at building an enhanced machine learning classifier that can be used for diagnosing cachexia syndrome and identifying its involved biomarkers. To achieve this goal, a data-driven analysis is carried out using a public dataset consisting of 1H-NMR metabolite profile. This dataset suffers from the problem of imbalanced classes...

FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FlyAtlas 2 (www.flyatlas2.org) is part successor, part complement to the FlyAtlas database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. Although generated in the same lab with the same fly line raised on the same diet as FlyAtlas, the FlyAtlas2 resource employs a completely new set of expression data based on ...